Human Necrotizing Vasculitis: Immunoglobulins and Complement in Vessel Walls of Cutaneous Lesions and Normal Skin

Immunoglobulins and C3 were detected by immunoflourescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically n...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 64; no. 6; pp. 441 - 445
Main Authors Sams, W Mitchell, Claman, Henry N., Kohler, Peter F., McIntosh, Rawle M., Small, Peter, Mass, M.F.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.1975
Subjects
Antigen-Antibody Complex
Blood Vessels - immunology
Blood Vessels - pathology
C-Reactive Protein - analysis
Complement C3 - analysis
Complement System Proteins - analysis
Fibrinogen - analysis
Fluorescent Antibody Technique
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Immunoglobulins - analysis
Polyarteritis Nodosa - immunology
Properdin - analysis
Skin - blood supply
Time Factors
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Summary:Immunoglobulins and C3 were detected by immunoflourescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically normal skin, 7 patients had C3 and 3 of these also had IgM or IgA. These findings support the hypothesis that immunoglobulins and complement are present in vessels of some patients prior to chemotaxis of polymorphonuclear leukocytes and the resulting inflammatory purpuric lesions so characteristic of necrotizing vasculitis.
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ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12512411