Human Necrotizing Vasculitis: Immunoglobulins and Complement in Vessel Walls of Cutaneous Lesions and Normal Skin
Immunoglobulins and C3 were detected by immunoflourescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically n...
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Published in | Journal of investigative dermatology Vol. 64; no. 6; pp. 441 - 445 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.06.1975
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Subjects | |
Online Access | Get full text |
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Summary: | Immunoglobulins and C3 were detected by immunoflourescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically normal skin, 7 patients had C3 and 3 of these also had IgM or IgA. These findings support the hypothesis that immunoglobulins and complement are present in vessels of some patients prior to chemotaxis of polymorphonuclear leukocytes and the resulting inflammatory purpuric lesions so characteristic of necrotizing vasculitis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-202X 1523-1747 |
DOI: | 10.1111/1523-1747.ep12512411 |