Proposing an adaptive mutation to improve XCSF performance to classify ADHD and BMD patients

• Published in: Journal of neural engineering Vol. 7; no. 6; p. 066006
• Main Authors: Sadatnezhad, Khadijeh, Boostani, Reza, Ghanizadeh, Ahmad
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.12.2010
• Subjects: Algorithms; Artificial Intelligence; Attention Deficit Disorder with Hyperactivity - classification; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - genetics; Bipolar Disorder - classification; Bipolar Disorder - diagnosis; Bipolar Disorder - genetics; Child; Data Interpretation, Statistical; Diagnosis, Differential; Discriminant Analysis; Electroencephalography; Fractals; Genotype; Humans; Linear Models; Reproducibility of Results
• ISSN: 1741-2552; 1741-2560; 1741-2552
• DOI: 10.1088/1741-2560/7/6/066006

There is extensive overlap of clinical symptoms observed among children with bipolar mood disorder (BMD) and those with attention deficit hyperactivity disorder (ADHD). Thus, diagnosis according to clinical symptoms cannot be very accurate. It is therefore desirable to develop quantitative criteria for automatic discrimination between these disorders. This study is aimed at designing an efficient decision maker to accurately classify ADHD and BMD patients by analyzing their electroencephalogram (EEG) signals. In this study, 22 channels of EEGs have been recorded from 21 subjects with ADHD and 22 individuals with BMD. Several informative features, such as fractal dimension, band power and autoregressive coefficients, were extracted from the recorded signals. Considering the multimodal overlapping distribution of the obtained features, linear discriminant analysis (LDA) was used to reduce the input dimension in a more separable space to make it more appropriate for the proposed classifier. A piecewise linear classifier based on the extended classifier system for function approximation (XCSF) was modified by developing an adaptive mutation rate, which was proportional to the genotypic content of best individuals and their fitness in each generation. The proposed operator controlled the trade-off between exploration and exploitation while maintaining the diversity in the classifier's population to avoid premature convergence. To assess the effectiveness of the proposed scheme, the extracted features were applied to support vector machine, LDA, nearest neighbor and XCSF classifiers. To evaluate the method, a noisy environment was simulated with different noise amplitudes. It is shown that the results of the proposed technique are more robust as compared to conventional classifiers. Statistical tests demonstrate that the proposed classifier is a promising method for discriminating between ADHD and BMD patients.