Potential hypotensive agents: synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds

A series of oxime ethers 1 and 2 have been synthesized and evaluated for their hypotensive activity. The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2- b]- and naphth[2,1- b]-oxepin-5-ones ( 4 and 8) were carried out. The hypotensive activity of oximino...

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Published inBioorganic & medicinal chemistry letters Vol. 14; no. 12; pp. 3177 - 3180
Main Authors Tandon, Vishnu K., Kumar, Manoj, Awasthi, Anoop K., Saxena, Hari O., Goswamy, Gajendra K.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 21.06.2004
Elsevier
Subjects
Animals
Antihypertensive agents
Antihypertensive Agents - chemical synthesis
Antihypertensive Agents - pharmacology
Biological and medical sciences
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiovascular system
Cats
Medical sciences
Miscellaneous
Oxepins - chemical synthesis
Oxepins - pharmacology
Oximes - chemical synthesis
Oximes - pharmacology
Pharmacology. Drug treatments
Fissipedia
Hypotensive drug
Carnivora
Vertebrata
Mammalia
Ether
Cat
Oxime
Chemical synthesis
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Summary:A series of oxime ethers 1 and 2 have been synthesized and evaluated for their hypotensive activity. The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2- b]- and naphth[2,1- b]-oxepin-5-ones ( 4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80 mm/Hg for >100′ at a dose of 5 mg/kg iv in anaesthetized cats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.04.009