A thermal signal generator probe for the study of neural thermal transduction

The study of thermal transduction in neural tissues has been impeded by the lack of instrumentation able to generate complex, focal temperature variations. Specifically, the authors are interested in the study of neural thermal transduction within the cornea, with its homogeneous thermal conductivit...

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Bibliographic Details
Published inIEEE transactions on biomedical engineering Vol. 41; no. 7; pp. 649 - 655
Main Authors Maluf, N.I., McNutt, E.L., Monroe, S., Tanelian, D.L., Kovacs, G.T.A.
Format Journal Article
LanguageEnglish
Published New York, NY IEEE 01.07.1994
Institute of Electrical and Electronics Engineers
Subjects
Action Potentials - physiology
Adaptation, Physiological
Animals
Biological and medical sciences
Body Temperature - physiology
Calibration
Cooling
Cornea
Cornea - physiology
Equipment Design
Heating
Impedance
In Vitro Techniques
Instruments
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nerve Tissue - physiology
Nervous system
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Probes
Rabbits
Signal generators
Signal Processing, Computer-Assisted
Temperature control
Temperature measurement
Thermal Conductivity
Thermometers
Cornea
Description
Rabbit
Thermal stimulus
Nervous system
Exploration
Lagomorpha
Experimental study
Thermal sensibility
Vertebrata
Mammalia
Thermoelectric device
Emissive probe
Animal
Apparatus
Technique
Computer aid
Biomedical engineering
Thermal conduction
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Summary:The study of thermal transduction in neural tissues has been impeded by the lack of instrumentation able to generate complex, focal temperature variations. Specifically, the authors are interested in the study of neural thermal transduction within the cornea, with its homogeneous thermal conductivity and avascularity. They present a thermal signal generator probe that is capable of producing arbitrarily shaped bipolar (heating or cooling) thermal swings in a small volume of corneal tissue with which it is in contact. Heating and cooling of the probe tip are achieved by means of a Peltier effect thermoelectric device. The probe temperature, measured directly at the tip, is controlled using closed-loop control circuitry and waveform generation software on a host computer. Response characteristics of thermally sensitive C-fibers were investigated in an in vitro preparation of the rabbit cornea.< >
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ISSN:0018-9294
1558-2531
DOI:10.1109/10.301731