Kinetics of high-sensitivity cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction

• Published in: Clinical chemistry and laboratory medicine Vol. 53; no. 5; pp. 707 - 714
• Main Authors: Solecki, Kamila, Dupuy, Anne Marie, Kuster, Nils, Leclercq, Florence, Gervasoni, Richard, Macia, Jean-Christophe, Cung, Thien-Tri, Lattuca, Benoit, Cransac, Frédéric, Cade, Stéphane, Pasquié, Jean-Luc, Cristol, Jean-Paul, Roubille, François
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.04.2015
• Subjects: Acute Disease; acute myocardial infarction; Biomarkers - blood; creatine kinase; Creatine Kinase - blood; Female; high-sensitivity troponin; Humans; Kinetics; Life Sciences; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - enzymology; Myocardial Infarction - surgery; Myocardial Revascularization; Myocardium - metabolism; percutaneous coronary intervention; Treatment Outcome; troponin I; Troponin I - blood; troponin T; Troponin T - blood
• ISSN: 1434-6621; 1437-4331
• DOI: 10.1515/cclm-2014-0475

Cardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity cardiac troponin T (hs-cTnT) raises concerns because of its unclear kinetic following the peak. This study aims to compare kinetics of cTnI and hs-cTnT to CK in patients with large AMI successfully treated by percutaneous coronary intervention (PCI). We prospectively studied 62 patients with anterior AMI successfully reperfused with primary angioplasty. We evaluated two consecutive groups: the first one regularly assessed by both CK and cTnI methods and the second group by CK and hs-cTnT. Modeling of kinetics was realized using mixed effects with cubic splines. Kinetics of markers showed a peak at 7.9 h for CK, at 10.9 h (6.9–12.75) for cTnI and at 12 h for hs-cTnT. This peak was followed by a nearly log linear decrease for cTnI and CK by contrast to hs-cTnT which appeared with a biphasic shape curve marked by a second peak at 82 h. There was no significant difference between the decrease of cTnI and CK (p=0.63). CK fell by 79.5% (76.1–99.9) vs. cTnI by 86.8% (76.6–92.7). In the hs-cTnT group there was a significant difference in the decrease by 26.5% (9–42.9) when compared with CK that fell by 79.5% (64.3–90.7). Kinetic of hs-cTnT and not cTnI differs from CK. The role of hs-cTnT in prognosis has to be investigated.