Effects of ketamine anaesthesia, stress and repeated bleeding on the haematology of vervet monkeys

• Published in: Laboratory animals (London) Vol. 19; no. 2; pp. 138 - 144
• Main Authors: Wall, H S, Worthman, C, Else, J G
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.1985
• Subjects: Analysis of Variance; Anesthesia - veterinary; Animals; Blood Cell Count; Bloodletting - veterinary; Cercopithecus - blood; Cercopithecus aethiops - blood; Female; Hematocrit; Hemoglobins - analysis; Ketamine - pharmacology; Leukocyte Count; Stress, Physiological - veterinary
• ISSN: 0023-6772; 1758-1117
• DOI: 10.1258/002367785780942633

Haematology values are presented for the vervet monkey (Cercopithecus aethiops), and the relative effects of high dose ketamine anaesthesia, stress of capture and repeated bleedings assessed. Anaesthesia resulted in decreased WBC and RBC values, attributed to depression of cardiovascular function. These effects were the reverse of those of alarm and strenuous exercise (leukocytosis and polycythaemia) during capture. Stress resulted in relatively high white and low red blood cell counts. Opposing effects of stress and anaesthesia led to comparable haematological values for trained, non-anaesthetized vervets and stressed, anaesthetized vervets. Effects of repeated bleedings were opposite in anaesthetized and non-anaesthetized animals. These effects, however, along with those of ketamine anaesthesia and stress, were relatively insignificant compared with the wide variation in haematological values found among individuals. The biological importance of these effects thus appeared to be slight. The concept of 'normal values' is discussed.