Autophagy in neural stem cells and glia for brain health and diseases

Autophagy is a multifaceted cellular process that not only maintains the homeostatic and adaptive responses of the brain but is also dynamically involved in the regulation of neural cell generation, maturation, and survival. Autophagy facilities the utilization of energy and the microenvironment for...

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Published inNeural regeneration research Vol. 19; no. 4; pp. 729 - 736
Main Authors Nagayach, Aarti, Wang, Chenran
Format Journal Article
LanguageEnglish
Published Mumbai Medknow Publications & Media Pvt. Ltd 01.04.2024
Department of Cancer Biology,University of Cincinnati College of Medicine,Cincinnati,OH,USA
Subjects
Autophagy
Stem cells
neurodegenerative diseases
autophagy
neural stem cells
oligodendrocyte
astrocyte
glia
microglia
neurodevelopmental disorders
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Abstract Autophagy is a multifaceted cellular process that not only maintains the homeostatic and adaptive responses of the brain but is also dynamically involved in the regulation of neural cell generation, maturation, and survival. Autophagy facilities the utilization of energy and the microenvironment for developing neural stem cells. Autophagy arbitrates structural and functional remodeling during the cell differentiation process. Autophagy also plays an indispensable role in the maintenance of stemness and homeostasis in neural stem cells during essential brain physiology and also in the instigation and progression of diseases. Only recently, studies have begun to shed light on autophagy regulation in glia (microglia, astrocyte, and oligodendrocyte) in the brain. Glial cells have attained relatively less consideration despite their unquestioned influence on various aspects of neural development, synaptic function, brain metabolism, cellular debris clearing, and restoration of damaged or injured tissues. Thus, this review composes pertinent information regarding the involvement of autophagy in neural stem cells and glial regulation and the role of this connexion in normal brain functions, neurodevelopmental disorders, and neurodegenerative diseases. This review will provide insight into establishing a concrete strategic approach for investigating pathological mechanisms and developing therapies for brain diseases.
AbstractList Autophagy is a multifaceted cellular process that not only maintains the homeostatic and adaptive responses of the brain but is also dynamically involved in the regulation of neural cell generation, maturation, and survival. Autophagy facilities the utilization of energy and the microenvironment for developing neural stem cells. Autophagy arbitrates structural and functional remodeling during the cell differentiation process. Autophagy also plays an indispensable role in the maintenance of stemness and homeostasis in neural stem cells during essential brain physiology and also in the instigation and progression of diseases. Only recently, studies have begun to shed light on autophagy regulation in glia (microglia, astrocyte, and oligodendrocyte) in the brain. Glial cells have attained relatively less consideration despite their unquestioned influence on various aspects of neural development, synaptic function, brain metabolism, cellular debris clearing, and restoration of damaged or injured tissues. Thus, this review composes pertinent information regarding the involvement of autophagy in neural stem cells and glial regulation and the role of this connexion in normal brain functions, neurodevelopmental disorders, and neurodegenerative diseases. This review will provide insight into establishing a concrete strategic approach for investigating pathological mechanisms and developing therapies for brain diseases.
Author Nagayach, Aarti
Wang, Chenran
AuthorAffiliation Department of Cancer Biology,University of Cincinnati College of Medicine,Cincinnati,OH,USA
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  surname: Wang
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  organization: Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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CitedBy_id crossref_primary_10_1016_j_ajhg_2024_02_001
crossref_primary_10_4103_NRR_NRR_D_23_01195
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Snippet Autophagy is a multifaceted cellular process that not only maintains the homeostatic and adaptive responses of the brain but is also dynamically involved in...
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SubjectTerms Autophagy
Stem cells
Title Autophagy in neural stem cells and glia for brain health and diseases
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Volume 19
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