Naloxone inhibits clomipramine in mouse forced swimming test

Naloxone inhibited the effect of clomipramine on duration of immobility of mice in the forced swimming test. This test is proposed as an antidepressant study model. It had previously been shown that naloxone inhibited the analgesic effect of the antidepressant clomipramine. Several hypotheses are co...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 78; no. 2; p. 229
Main Authors Devoize, J L, Rigal, F, Eschalier, A, Trolese, J F
Format Journal Article
LanguageEnglish
Published Netherlands 26.02.1982
Subjects
Animals
Clomipramine - antagonists & inhibitors
Escape Reaction - drug effects
Male
Mice
Naloxone - pharmacology
Physical Exertion
Swimming
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Summary:Naloxone inhibited the effect of clomipramine on duration of immobility of mice in the forced swimming test. This test is proposed as an antidepressant study model. It had previously been shown that naloxone inhibited the analgesic effect of the antidepressant clomipramine. Several hypotheses are considered for the mechanism of the naloxone-clomipramine antagonism.
ISSN:0014-2999
DOI:10.1016/0014-2999(82)90241-2