Effects of maternal deprivation of CD1 mice on performance in the water maze and swim stress

Rat pups subjected to a single 24 h maternal deprivation show altered stress responsiveness and cognitive performance in the water maze in adulthood. Here we show in 6-month-old male CD1 mice (deprived 24 h at postnatal day 8) an initial impairment in reversal learning: relocating the platform revea...

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Bibliographic Details
Published inBehavioural brain research Vol. 187; no. 1; pp. 195 - 199
Main Authors Enthoven, L., de Kloet, E.R., Oitzl, M.S.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 11.02.2008
Subjects
Animals
Behaviour
Corticosterone
Corticosterone - blood
Female
HPA axis
Male
Maternal Deprivation
Maze Learning - physiology
Mice
Psychomotor Performance - physiology
Reinforcement Schedule
Stress, Psychological - blood
Stress, Psychological - psychology
Swimming - psychology
Water maze
Mice
HPA axis
Maternal deprivation
Behaviour
Corticosterone
Water maze
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Summary:Rat pups subjected to a single 24 h maternal deprivation show altered stress responsiveness and cognitive performance in the water maze in adulthood. Here we show in 6-month-old male CD1 mice (deprived 24 h at postnatal day 8) an initial impairment in reversal learning: relocating the platform revealed perseverance in search for the former location. Spatial learning, long-term memory and swim-induced corticosterone responses were not affected. We conclude that reduced flexibility is a subtle long-lasting behavioural change induced by maternal deprivation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2007.08.037