Biomarkers of cholestasis

Cholestasis is a major pathological manifestation, often resulting in detrimental liver conditions, which occurs in a variety of indications collectively termed cholestatic liver diseases. The frequent asymptomatic character and complexity of cholestasis, together with the lack of a straightforward...

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Published inBiomarkers in medicine Vol. 15; no. 6; pp. 437 - 454
Main Authors Pieters, Alanah, Gijbels, Eva, Cogliati, Bruno, Annaert, Pieter, Devisscher, Lindsey, Vinken, Mathieu
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.04.2021
Subjects
Animals
biomarker
Biomarkers - metabolism
cholestasis
Cholestasis - diagnosis
Cholestasis - metabolism
Humans
liver
Liver - metabolism
Liver - pathology
Liver Diseases - diagnosis
Liver Diseases - metabolism
omics
omics
biomarker
cholestasis
liver
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Summary:Cholestasis is a major pathological manifestation, often resulting in detrimental liver conditions, which occurs in a variety of indications collectively termed cholestatic liver diseases. The frequent asymptomatic character and complexity of cholestasis, together with the lack of a straightforward biomarker, hampers early detection and treatment of the condition. The ‘omics’ era, however, has resulted in a plethora of cholestatic indicators, yet a single clinically applicable biomarker for a given cholestatic disease remains missing. The criteria to fulfil as an ideal biomarker as well as the challenging molecular pathways in cholestatic liver diseases advocate for a scenario in which multiple biomarkers, originating from different domains, will be assessed concomitantly. This review gives an overview of classical clinical and novel molecular biomarkers in cholestasis, focusing on their benefits and drawbacks.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2020-0691