Exosomes in malignant pleural effusions: Sources and applications

• Published in: Chinese medical journal Vol. 137; no. 11; pp. 1381 - 1383
• Main Authors: Huang, Yueyu, Wang, Jiahui, Yao, Qifeng, Yang, Xuping, Ye, Xuemei, Liu, Junping, Wang, Changchun, Zhou, Bin, Li, Shuang, Su, Bin, Mao, Weimin, Zhao, An
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins Ovid Technologies 05.06.2024; Lippincott Williams & Wilkins; Wolters Kluwer
• Subjects: Antigens; Biomarkers; Correspondence; Exosomes - metabolism; Humans; Kinases; Lung cancer; Lung diseases; Lymphocytes; Medical prognosis; Mesothelioma; Metastasis; MicroRNAs; Mutation; Pleural effusion; Pleural Effusion, Malignant; Tuberculosis; Tumors; Jiangxi China; China
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.1097/CM9.0000000000003078

Increased evidence has shown that exosomes are related to the development of MPE and are correlated with the efficacy of and response to targeted therapy or immunotherapy. Tamiya et al[9] reported that exosomal miRNA-182 and miRNA-210 could differentiate between benign and malignant cases of lung adenocarcinoma, and they suggested that analysis of MPE-associated exosomes may be a more accurate approach for diagnosing and monitoring lung cancer, as there was no correlation between miRNA expression in serum and pleural effusions. [13] Exosomes derived from MPE are ideal carriers that can overcome the limitations of conventional drugs in several ways: (1) exosomes can be obtained from a variety of sources and are widely distributed throughout the human body; (2) when exosomes are obtained from autologous sources, they have low toxicity and controllable immunogenicity; (3) exosomes can penetrate the blood–brain barrier and transport various substrates to the target site; (4) proteins on the surface of exosome membranes can serve as ligands or receptors, enhancing their targeting ability; and (5) exosomes can also stimulate the immune system through antigen presentation. Proteomic analysis of exosomes isolated from human malignant pleural effusions.