Investigation of hematologic findings related to brucellosis in Anatolian region

• Published in: Saudi medical journal Vol. 45; no. 5; pp. 495 - 501
• Main Authors: Çelik, Mehmet, Arslan, Yusuf, Topcu, Ertuğrul, Serhat Şahinoğlu, Mustafa, Altındağ, Deniz, Gürbüz, Esra, Atalay, Ebru, Kışlak Demircan, Sümeyye, Emre, Salih, Kırık, Yasemin, Yürük Atasoy, Pınar, Özer, Deniz, İpek, Davut, Doğan, Ebru, Bilgiç Atlı, Seval, Gülderen Kuşçu, Evrim, Alkan, Sevil, Çiçek, Yeliz, Yüksekkaya, Esra, Aldemir, Özlem, Şahin, Ahmet, Yekta Ürkmez, Fatma, Özdemir Al, Sevda, Boran, Riyad, Oğuz Mızrakçı, Serpil, Kübra Dindar Demiray, Emine, Reşat Ceylan, Mehmet, Erdoğdu, Hamza, Tekin, Süda
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Saudi Medical Journal 01.05.2024
• Subjects: Adolescent; Adult; Aged; Anemia - blood; Anemia - epidemiology; Anemia - etiology; Blood Cell Count; Blood diseases; Brucellosis; Brucellosis - blood; Brucellosis - complications; Brucellosis - epidemiology; Complications and side effects; Female; Humans; Male; Middle Aged; Original; Risk factors; Statistics; Thrombocytopenia - blood; Thrombocytopenia - epidemiology; Turkey - epidemiology; Young Adult; Turkey; hematologic; monocytosis; eosinopenia; anemia; brucellosis
• ISSN: 0379-5284; 1658-3175
• DOI: 10.15537/smj.2024.45.5.20230847

To investigate the prevalence of hematologic findings and the relationship between hemogram parameters and brucellosis stages in patients. This multi-center study included patients older than 16 years of age who were followed up with a diagnosis of brucellosis. Patients' results, including white blood cell, hemoglobin, neutrophil, lymphocyte, monocyte, mean platelet volume, platelet and eosinophil counts were analyzed at the initial diagnosis. In this study 51.3% of the patients diagnosed with brucellosis were male. The age median was 45 years for female and 41 years for male. A total of 55.1% of the patients had acute brucellosis, 28.2% had subacute, 7.4% had chronic and 9% had relapse. The most common hematologic findings in brucellosis patients were anemia (25.9%), monocytosis (15.9%), eosinopenia (10.3%), and leukocytosis (7.1%). Pancytopenia occurred in 0.8% of patients and was more prominent in the acute phase. The acute brucellosis group had lower white blood cell, hemoglobin, neutrophil, eosinophil, and platelet counts and mean platelet volume, and higher monocyte counts compared to subacute and chronic subgroups. It was noteworthy that in addition to anemia and monocytosis, eosinopenia was third most prominent laboratory findings in the study. Pancytopenia and thrombocytopenia rates were low.