Another way to die: autophagic programmed cell death

Programmed cell death (PCD) is one of the important terminal paths for the cells of metazoans, and is involved in a variety of biological events that include morphogenesis, maintenance of tissue homeostasis, and elimination of harmful cells. Dysfunction of PCD leads to various diseases in humans, in...

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Published inCell death and differentiation Vol. 12; no. S2; pp. 1528 - 1534
Main Authors Tsujimoto, Y, Shimizu, S
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.11.2005
Subjects
Animals
Apoptosis - physiology
Autophagy - physiology
Cell death
Humans
JNK Mitogen-Activated Protein Kinases - physiology
Phagocytosis
Phagosomes - physiology
Proto-Oncogene Proteins c-bcl-2 - physiology
Signal Transduction
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Summary:Programmed cell death (PCD) is one of the important terminal paths for the cells of metazoans, and is involved in a variety of biological events that include morphogenesis, maintenance of tissue homeostasis, and elimination of harmful cells. Dysfunction of PCD leads to various diseases in humans, including cancer and several degenerative diseases. Apoptosis is not the only form of PCD. Recent studies have provided evidence that there is another mechanism of PCD, which is associated with the appearance of autophagosomes and depends on autophagy proteins. This form of cell death most likely corresponds to a process that has been morphologically defined as autophagic PCD. The present review summarizes recent experimental evidence about autophagic PCD and discusses some aspects of this form of cell death, including the mechanisms that may distinguish autophagic death from the process of autophagy involved in cell survival.
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ObjectType-Review-1
ISSN:1350-9047
1476-5403
DOI:10.1038/sj.cdd.4401777