De novo CD5-positive diffuse large B-cell lymphoma of the skin arising in chronic limb lymphedema

• Published in: Leukemia & lymphoma Vol. 46; no. 5; pp. 775 - 780
• Main Authors: Dargent, Jean-Louis, Lespagnard, Laurence, Feoli, Francesco, Debusscher, Louisette, Greuse, Muriel, Bron, Dominique
• Format: Journal Article
• Language: English
• Published: United States Informa UK Ltd 01.05.2005
• Subjects: Aged; Arm; CD5 Antigens - biosynthesis; Chronic Disease; Epstein-Barr virus; Female; Humans; Lymphedema - complications; Lymphedema - immunology; Lymphedema - pathology; Lymphoma, B-Cell - complications; Lymphoma, B-Cell - immunology; Lymphoma, B-Cell - pathology; Lymphoma, Large B-Cell, Diffuse - complications; Lymphoma, Large B-Cell, Diffuse - immunology; Lymphoma, Large B-Cell, Diffuse - pathology; Polymerase Chain Reaction; Skin Neoplasms - complications; Skin Neoplasms - immunology; Skin Neoplasms - pathology
• ISSN: 1042-8194; 1029-2403
• DOI: 10.1080/10428190500051208

We report the case of a 79-year-old woman with a longstanding lymphedema of the right arm who developed a skin lymphoma involving the right wrist area. Microscopically, the lesion was composed of numerous centroblasts infiltrating both the dermis and the subcutaneous tissue. Phenotypic investigations showed expression of CD20, CD79a, and bcl-2 protein by neoplastic cells. In addition, these cells were CD5 positive. No expression of anaplastic large cell lymphoma kinase (ALK), CD10, CD23, CD30, CD43, bcl-6, cyclin D1, p53 or p16INK4a could be seen. Polymerase chain reaction (PCR) analysis demonstrated a clonal rearrangement of the genes coding for the kappa light chain of the immunoglobulin (Ig). No rearrangement of the genes coding for the Ig heavy chain, t(14;18) or t(11;14) chromosome translocations, or Epstein-Barr virus (EBV) genomic sequences could be found. The tumor was classified as stage IE and was first cured by complete surgical excision. Nineteen months later, a recurrence was noted in the right elbow area. This study further illustrates that lymphoma of the skin may complicate chronic limb lymphedema. Like most of the previously reported cases, this neoplasm belonged to the category of diffuse large B-cell lymphoma. However, it showed CD5 expression as a singular feature.