Control of protein translation by phosphorylation of the mRNA 5'-cap-binding complex

Initiation of mRNA translation is a key regulatory step in the control of gene expression. Microarray analysis indicates that total mRNA levels do not always reflect protein levels, since mRNA association with polyribosomes is necessary for protein synthesis. Phosphorylation of translation initiatio...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 35; no. Pt 6; p. 1634
Main Authors Pierrat, O A, Mikitova, V, Bush, M S, Browning, K S, Doonan, J H
Format Journal Article
LanguageEnglish
Published England 01.12.2007
Subjects
Peptide Initiation Factors - genetics
Peptide Initiation Factors - metabolism
Phosphorylation
Plants - genetics
Plants - metabolism
RNA Cap-Binding Proteins - genetics
RNA Cap-Binding Proteins - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:Initiation of mRNA translation is a key regulatory step in the control of gene expression. Microarray analysis indicates that total mRNA levels do not always reflect protein levels, since mRNA association with polyribosomes is necessary for protein synthesis. Phosphorylation of translation initiation factors offers a cost-effective and rapid way to adapt to physiological and environmental changes, and there is increasing evidence that many of these factors are subject to multiple regulatory phosphorylation events. The present article focuses on the nature of reversible phosphorylation and the function of the 5'-cap-binding complex in plants.
ISSN:0300-5127
DOI:10.1042/bst0351634