β-Lactam antibiotic resistance: a current structural perspective

Bacterial resistance to β-lactam antibiotics can be achieved by any of three strategies: the production of β-lactam-hydrolyzing β-lactamase enzymes, the utilization of β-lactam-insensitive cell wall transpeptidases, and the active expulsion of β-lactam molecules from Gram-negative cells by way of ef...

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Bibliographic Details
Published inCurrent opinion in microbiology Vol. 8; no. 5; pp. 525 - 533
Main Authors Wilke, Mark S, Lovering, Andrew L, Strynadka, Natalie CJ
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2005
Subjects
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - metabolism
beta-Lactam Resistance
beta-Lactamases - chemistry
beta-Lactamases - metabolism
beta-Lactams - chemistry
beta-Lactams - metabolism
beta-Lactams - pharmacology
Biological Transport, Active
Drug Design
Models, Molecular
Molecular Structure
Penicillin-Binding Proteins - chemistry
Penicillin-Binding Proteins - metabolism
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Summary:Bacterial resistance to β-lactam antibiotics can be achieved by any of three strategies: the production of β-lactam-hydrolyzing β-lactamase enzymes, the utilization of β-lactam-insensitive cell wall transpeptidases, and the active expulsion of β-lactam molecules from Gram-negative cells by way of efflux pumps. In recent years, structural biology has contributed significantly to the understanding of these processes and should prove invaluable in the design of drugs to combat β-lactam resistance in the future.
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ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2005.08.016