Synthesis and antibacterial activity of oxazolidinone derivatives containing nitro heteroaromatic moiety

A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of 1 H NMR and MS spectra. All target compounds were evaluated for their in vitro antibac-terial activities against S.au 29213, methicillin-resistant Staphylococcus aureus (M...

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Published inChemical research in Chinese universities Vol. 34; no. 1; pp. 51 - 56
Main Authors Xu, Boxuan, Ding, Xiudong, Wu, Yachuang, Cui, Lei, Qian, Ping, Wang, Di, Zhao, Yanfang
Format Journal Article
LanguageEnglish
Published Changchun Jilin University and The Editorial Department of Chemical Research in Chinese Universities 01.02.2018
Springer Nature B.V
Subjects
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Inorganic Chemistry
NMR
Nuclear magnetic resonance
Organic Chemistry
Physical Chemistry
Staphylococcus infections
Vancomycin
Linezolid
Antibacterial activity
Ranbezolid
Oxazolidinone derivative
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Summary:A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of 1 H NMR and MS spectra. All target compounds were evaluated for their in vitro antibac-terial activities against S.au 29213, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S.au 29213, MRSA and VRE. Among them, compounds 10 e and 10 f displayed better activity than the control.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-018-7302-3