Novel pH-responsive biodegradable organosilica nanoparticles as drug delivery system for cancer therapy

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Vol. 585; p. 124133
• Main Authors: Yang, Shun, Fan, Jie, Lin, Shiting, Wang, Yaru, Liu, Chang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.01.2020
• Subjects: antineoplastic agents; biodegradability; Biodegradable; biodegradation; cancer therapy; Drug delivery; drug delivery systems; excretion; moieties; nanoparticles; neoplasm cells; neoplasms; Organosilica; pH-responsive; porous media; silica; silsesquioxanes; toxicity; Drug delivery; Biodegradable; pH-responsive; Organosilica

Novel biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane was successfully prepared for efficient anti-cancer drug delivery. [Display omitted] Although the biodegradability of silica has been verified, the complete and safe excretion of mesoporo...