Novel pH-responsive biodegradable organosilica nanoparticles as drug delivery system for cancer therapy

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Vol. 585; p. 124133
• Main Authors: Yang, Shun, Fan, Jie, Lin, Shiting, Wang, Yaru, Liu, Chang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.01.2020
• Subjects: antineoplastic agents; biodegradability; Biodegradable; biodegradation; cancer therapy; Drug delivery; drug delivery systems; excretion; moieties; nanoparticles; neoplasm cells; neoplasms; Organosilica; pH-responsive; porous media; silica; silsesquioxanes; toxicity; Drug delivery; Biodegradable; pH-responsive; Organosilica
• ISSN: 0927-7757; 1873-4359
• DOI: 10.1016/j.colsurfa.2019.124133

Novel biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane was successfully prepared for efficient anti-cancer drug delivery. [Display omitted] Although the biodegradability of silica has been verified, the complete and safe excretion of mesoporous silica nanoparticles (MSNs) from the biological system still impede their clinical translation. Herein, novel pH-responsive biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane were successfully prepared for efficient anti-cancer drug delivery. pH-responsive cleavable bridges containing acetal moieties were prepared and then inserted directly into the framework of the MONs and the hollow nanostructures were achieved by silica-etching chemistry (alkaline etching). PBHMONs exhibited particularly high drug loading capacities for drugs (DOX) owing to the hollow mesoporous structure, and a uniquely low premature leakage owing to π-π interactions. Moreover, the pH-responsive biodegradation of the PBHMONs in the weakly acidic microenvironment of tumor cells led to partial drug release, as well as potential enabling rapid excretion and preventing long-term retention/toxicity.