Tacalcitol ointment for the treatment of nail psoriasis

• Published in: The Journal of dermatological treatment Vol. 20; no. 5; pp. 308 - 310
• Main Authors: Balbás, Gemma Márquez, Regaña, Manuel Sánchez, Millet, Pablo Umbert
• Format: Journal Article
• Language: English
• Published: Oslo Informa UK Ltd 2009; Taylor & Francis
• Subjects: Administration, Topical; Biological and medical sciences; Dermatologic Agents - therapeutic use; Dermatology; Dihydroxycholecalciferols - therapeutic use; Female; Follow-Up Studies; Humans; Male; Medical sciences; Nail Diseases - drug therapy; Nail Diseases - pathology; Ointments; Pharmacology. Drug treatments; Psoriasis - drug therapy; Psoriasis - pathology; Psoriasis. Parapsoriasis. Lichen; Skin, nail, hair, dermoskeleton; Treatment Outcome; Performance evaluation; Human; Skin disease; Psoriasis; Treatment efficiency; Antipsoriatic agent; Ointment; Route of administration; Tacalcitol; Nail(anatomy); Treatment; Vitamin D; nail psoriasis; vitamin D derivates; Nail disease
• ISSN: 0954-6634; 1471-1753
• DOI: 10.1080/09546630902787585

Tacalcitol is a vitamin D analog with proven efficacy for the topical treatment of psoriasis, but to date it has not been tested in psoriasis of the nail. However, successful treatment has been reported with other vitamin D derivatives such as topical calcipotriol, and topical calcitriol in one study. The present study aimed to assess the efficacy and tolerability of topical tacalcitol in the treatment of nail psoriasis in a sample of 15 patients over a 6-month period. Treatment with tacalcitol ointment may be useful to treat nail psoriasis as it achieves a significant improvement in all nail parameters, both of the matrix and of the bed.