Serum Levels of Circulating Adhesion Molecules after Coronary Angioplasty

• Published in: Cardiology Vol. 91; no. 4; pp. 236 - 242
• Main Authors: Inoue, Teruo, Hoshi, Kazuhiro, Yaguchi, Isao, Iwasaki, Yoichi, Takayanagi, Kan, Morooka, Shigenori
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.1999; S. Karger AG
• Subjects: Analysis of Variance; Angioplasty, Balloon, Coronary - adverse effects; Biological and medical sciences; Cardiac Catheterization and Interventional Cardiology; Cell Adhesion Molecules - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - therapy; Coronary Vessels - injuries; Diseases of the cardiovascular system; E-Selectin - blood; Endothelium, Vascular - physiology; Female; Follow-Up Studies; Humans; Intercellular Adhesion Molecule-1 - blood; L-Selectin - blood; Leukocytes - physiology; Male; Medical sciences; Middle Aged; P-Selectin - blood; Platelet Activation - physiology; Radiography; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recurrence; Regression Analysis; Vasculitis - etiology; Restenosis; Adhesion molecules; Coronary angioplasty; Pathophysiology; Angioplasty; Vasculature; Human; Treatment; Pathogenesis; Coronary artery; Cell adhesion molecule; Instrumentation therapy; Complication; Serum; Instrumental dilatation; Adhesion
• ISSN: 0008-6312; 1421-9751
• DOI: 10.1159/000006917

The activation of platelets, leukocytes, and vascular endothelial cells mediated by cell adhesion molecules may play a role in the mechanism of restenosis, which is still a significant complication after coronary angioplasty. We observed serial changes in the circulating soluble forms of adhesion molecules in 25 patients with coronary artery disease who underwent coronary angioplasty for a single lesion of the left anterior descending artery. Serum levels of sICAM-1 (p < 0.05) and sP-selectin (p < 0.05) were significantly increased immediately after angioplasty in the coronary sinus blood samples. These increases continued during the 48-hour observation period, and the maximum increase was seen 48 h after angioplasty for sICAM-1 (p < 0.01) and 24 h after angioplasty for sP-selectin (p < 0.01). The level of sL-selectin increased 24 h (p < 0.01) and 48 h (p < 0.001) after angioplasty. These changes were not observed in the peripheral blood samples. The sE-selectin level did not change after angioplasty. A multiple regression analysis showed that the late loss index obtained from quantitative angiographic (QCA) analysis was correlated with the changes in sICAM-1 (r = 0.31, p < 0.05), sL-selectin (r = 0.28, p < 0.05), and sP-selectin (r = 0.26, p < 0.05) 48 h after angioplasty in the coronary sinus blood samples, but was not correlated with procedural variables, other QCA variables, or the change in the sL-selectin level. The measurements of these adhesion molecule levels may help to evaluate traumatic vessel wall injury and inflammation at the intervention site after coronary angioplasty.