Repulsion or adhesion: receptors make the call

Repulsive signaling plays a prominent role in regulating cell–cell interactions and is fundamental to multiple developmental processes. A proper balance between repulsion from and adhesion to other cells or the extracellular matrix is also important. Semaphorin–Plexin and ephrin–Eph ligand–receptor...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 18; no. 5; pp. 533 - 540
Main Authors Halloran, Mary C, Wolman, Marc A
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2006
Subjects
Cell Adhesion - physiology
Cell Adhesion Molecules - metabolism
Ephrins - metabolism
Models, Biological
Nerve Tissue Proteins - metabolism
Semaphorins - metabolism
Signal Transduction - physiology
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Summary:Repulsive signaling plays a prominent role in regulating cell–cell interactions and is fundamental to multiple developmental processes. A proper balance between repulsion from and adhesion to other cells or the extracellular matrix is also important. Semaphorin–Plexin and ephrin–Eph ligand–receptor pairs compose two major repulsive signaling systems. Recent advances have elucidated mechanisms by which Semaphorin–Plexin and ephrin–Eph signaling control repulsion versus adhesion. Semaphorins act through a complex signaling pathway to inhibit integrin-mediated adhesion, allowing cell repulsion. Ephrin–Eph interactions can directly mediate cell adhesion and several mechanisms control whether ephrin–Eph binding and signaling induces repulsion or adhesion.
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ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2006.08.010