Synthesis of C8-linked pyrrolo[2,1- c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Graphic Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 14; no. 15; pp. 4107 - 4111
Main Authors Kamal, Ahmed, Srinivas, O, Ramulu, P, Ramesh, G, Kumar, P.Praveen
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 02.08.2004
Elsevier
Subjects
Acridine
Acridines - chemical synthesis
Acridines - chemistry
Acridone
Acridones
Antineoplastic agents
Benzodiazepines - chemical synthesis
Benzodiazepines - chemistry
Binding Sites
Biological and medical sciences
DNA - chemistry
DNA - metabolism
DNA-binding affinity
General aspects
In vitro anticancer activity
Medical sciences
Miscellaneous
Molecular Conformation
Molecular Structure
Pharmacology. Drug treatments
Pyrrolobenzodiazepine
Structure-Activity Relationship
DNA-binding affinity
Acridine
In vitro anticancer activity
Pyrrolobenzodiazepine
Acridone
Antineoplastic agent
Biological fixation
Acridine derivatives
DNA
Chemical synthesis
In vitro
Biological activity
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Summary:Graphic Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.04.087