Synthesis of C8-linked pyrrolo[2,1- c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents
Graphic Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
Saved in:
Published in | Bioorganic & medicinal chemistry letters Vol. 14; no. 15; pp. 4107 - 4111 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
02.08.2004
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Graphic
Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2004.04.087 |