α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently

• Published in: Neuroscience letters Vol. 409; no. 3; pp. 168 - 172
• Main Authors: Cragnolini, Andrea Beatriz, Caruso, Carla, Lasaga, Mercedes, Scimonelli, Teresa Nieves
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 06.12.2006; Elsevier
• Subjects: Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Hypothalamus; Interleukin-1β; Melanocortins; Nitric oxide; Prostaglandin; Vertebrates: nervous system and sense organs; Melanocortins; Hypothalamus; Prostaglandin; Nitric oxide; Interleukin-1β; α-Melanocyte stimulating hormone; Arachidonic acid derivatives; Central nervous system; γ-Melanocyte stimulating hormone; Melanocortin receptor; Encephalon; Pituitary hormone; Eicosanoid; Early; Release
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2006.09.034

Interleukin-1β (IL-1β) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). We have demonstrated that melanocortins can inhibit the early effects of IL-1β on the HPA axis by acting on the central nervous system (CNS). Our study investigated whether α-melanocyte stimulating hormone (α-MSH) and γ-MSH could inhibit IL-1β-induced PGE2 and NO release in hypothalamus in the rapid activation of the HPA axis. An i.c.v. injection of 12.5 ng/μl of IL-1β significantly increased the release of PGE2 and NOS activity in the hypothalamus. Treatment with α-MSH (0.1 μg/μl) inhibited the effect of IL-1β on PGE2 release. Also, γ-MSH (1 μg/μl) eliminated the increase in NOS activity induced by IL-1β. Our data indicate the modulatory role of melanocortins in the early hypothalamic response to IL-1β, with different regulation of PGE2 and NO release.