A Raman spectroscopic study of the diclofenac sodium–β-cyclodextrin interaction

• Published in: European journal of pharmaceutical sciences Vol. 22; no. 5; pp. 487 - 495
• Main Authors: Iliescu, T, Baia, M, Miclăuş, V
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.08.2004; Elsevier
• Subjects: 1:1 DCFNa–βCD complex; beta-Cyclodextrins - chemistry; beta-Cyclodextrins - metabolism; beta-Cyclodextrins - pharmacology; Biological and medical sciences; Diclofenac - chemistry; Diclofenac - metabolism; Diclofenac - pharmacology; Diclofenac sodium (DCFNa); Drug Interactions; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Raman and SERS spectroscopy; Spectrum Analysis, Raman - methods; β-Cyclodextrin (βCD); Diclofenac sodium (DCFNa); β-Cyclodextrin (βCD); 1:1 DCFNa–βCD complex; Raman and SERS spectroscopy; 1:1 DCFNa-βCD complex; Prostaglandin-endoperoxide synthase; Pharmaceutical technology; Enzyme; Interaction; Enzyme inhibitor; Diclofenac; Non steroidal antiinflammatory agent; β-Cyclodextrin; Arylacetic acid derivatives; Analgesic; Antipyretic; Oxidoreductases; Inclusion compound
• ISSN: 0928-0987; 1879-0720
• DOI: 10.1016/j.ejps.2004.05.003

The inclusion complex of diclofenac sodium (DCFNa) and β-cyclodextrin (βCD) was prepared and analyzed by using Raman and SERS spectroscopy. The interaction between DCFNa and βCD molecules was evidenced by monitoring the change in the peak positions and the widths of some guest molecule bands relative to those observed in the spectra of the free compound and 1:1 DCFNa–βCD physical mixture. Raman data have shown that the interaction between the guest and host molecules in the 1:1 DCFNa–βCD complex is maintained both through the dichlorophenyl ring and the phenylacetate group. SER spectra revealed that depending on the pH value of the solution different isomeric forms of the 1:1 guest–host complex are preferentially adsorbed on the silver surface via the nonbonding electrons of the oxygen atom. The orientation of the adsorbed species with respect to the metal surface was also elucidated.