Effect of oxazolidinone, RBx 7644 (ranbezolid), on inhibition of staphylococcal adherence to plastic surfaces

• Published in: Journal of chemotherapy (Florence) Vol. 20; no. 4; p. 420
• Main Authors: Mathur, T, Singhal, S, Khan, S, Bhateja, P, Pandya, M, Rattan, A, Bhatnagar, P K, Upadhyay, D J, Fatma, T
• Format: Journal Article
• Language: English
• Published: England 01.08.2008
• Subjects: Acetamides - pharmacology; Anti-Bacterial Agents - pharmacology; Bacterial Adhesion - drug effects; Biofilms - drug effects; Dose-Response Relationship, Drug; Furans - pharmacology; Linezolid; Microbial Sensitivity Tests; Oxazoles - pharmacology; Oxazolidinones - pharmacology; Plastics; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development; Staphylococcus epidermidis - drug effects; Staphylococcus epidermidis - growth & development; Time Factors; Vancomycin - pharmacology; Virginiamycin - pharmacology
• ISSN: 1973-9478
• DOI: 10.1179/joc.2008.20.4.420

Adhesion to biomaterial is assumed to be a crucial step in the pathogenesis of foreign body infection. Slime producing Staphylococcus epidermidis and Staphylococcus aureus have emerged as a preeminent cause of nosocomial bacteremia and infections of prosthetic medical devices. We evaluated the time-dependent anti-adhesive effect of RBx 7644 (ranbezolid), vancomycin, linezolid and quinupristin/ dalfopristin on two isolates each of S. epidermidis and S. aureus. Linezolid and quinupristin/ dalfopristin showed inhibition only at supra-inhibitory concentrations (2 and 4X MIC) following 2 and 4 h delayed treatment, whereas RBx 7644 demonstrated significant activity against adhesion of staphylococcal cells that had been treated with 2 to 6 h delay. When vancomycin treatment was delayed by 4 to 6 h, even concentrations above the MIC were unable to prevent adherence. This study indicates that RBx 7644 has anti-adhesion potential and may emerge as an important antibiotic for prevention and treatment of device-related infections caused by staphylococci.