Inflammatory Large Bowel Disease in Immunodeficient Rats Naturally and Experimentally Infected with Helicobacter bilis

Proliferative and ulcerative typhlitis, colitis, and proctitis were found incidentally in a breeding colony of male athymic nude (Cr:NIH-rnu) rats. Within the crypts of the large intestine, modified Steiner's silver stain revealed spiral organisms that were identified by culture, polymerase cha...

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Bibliographic Details
Published inVeterinary pathology Vol. 35; no. 3; pp. 202 - 208
Main Authors Haines, D. C., Gorelick, P. L., Battles, J. K., Pike, K. M., Anderson, R. J., Fox, J. G., Taylor, N. S., Shen, Z., Dewhirst, F. E., Anver, M. R., Ward, J. M.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.05.1998
Subjects
Animals
DNA Primers - chemistry
Feces - microbiology
Helicobacter - genetics
Helicobacter - isolation & purification
Helicobacter - ultrastructure
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter Infections - veterinary
Inflammatory Bowel Diseases - microbiology
Inflammatory Bowel Diseases - pathology
Inflammatory Bowel Diseases - veterinary
Intestine, Large - microbiology
Intestine, Large - pathology
Male
Polymerase Chain Reaction - veterinary
Proctitis - microbiology
Proctitis - pathology
Proctitis - veterinary
Rats
Rats, Nude
Rodent Diseases - microbiology
Rodent Diseases - pathology
Specific Pathogen-Free Organisms
typhlitis
Colitis
nude rats
Helicobacter
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Summary:Proliferative and ulcerative typhlitis, colitis, and proctitis were found incidentally in a breeding colony of male athymic nude (Cr:NIH-rnu) rats. Within the crypts of the large intestine, modified Steiner's silver stain revealed spiral organisms that were identified by culture, polymerase chain reaction, and sequencing to be Helicobacter bilis. The large bowel disease was reproduced in H. bilis-free male athymic nude rats that were injected intraperitoneally with a culture of H. bilis from the affected colony. The organism was isolated from the feces and cecum of the experimentally infected rats. H. bilis should be considered a potential pathogen in immunocompromised rats. The infection in immunocompromised rats may serve as an animal model for inflammatory large bowel disease.
Bibliography:ObjectType-Article-1
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ISSN:0300-9858
1544-2217
DOI:10.1177/030098589803500305