Spotlighting "Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps": A New Catch in Cystic Fibrosis?

Helms and Liou discuss the paper by Kummarapurugu et al. on the role of neutrophil elastase (NE) in the release of macrophage extracellular traps (MET) in cystic fibrosis (CF). They report that NE promotes MET release in human blood monocyte--derived macrophages (hBMDM) from subjects with and withou...

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Bibliographic Details
Published inAmerican journal of respiratory cell and molecular biology Vol. 66; no. 1; pp. 5 - 7
Main Authors Helms, My N, Liou, Theodore G
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.01.2022
Subjects
Alveoli
Cystic Fibrosis
Elastase
Extracellular matrix
Extracellular Traps
Humans
Leukocyte Elastase
Leukocytes (neutrophilic)
Macrophages
Monocytes
Neutrophils
Pathogenesis
Rodents
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Summary:Helms and Liou discuss the paper by Kummarapurugu et al. on the role of neutrophil elastase (NE) in the release of macrophage extracellular traps (MET) in cystic fibrosis (CF). They report that NE promotes MET release in human blood monocyte--derived macrophages (hBMDM) from subjects with and without CF as well as from alveolar macrophages (AMs) harvested from Cftr-null and wild-type mouse littermates. The role of METs in the pathogenesis of CF, as implied by the authors, requires additional study. Their initial approach involved classic reductionism, involving the study of hBMDM in vitro, which eliminates the possibility of mistaking previously confirmed NETosis in vivo for METosis. The authors proceeded to demonstrate that non-CF BMDMs release significantly higher proportions of METs compared with CF BMDMs.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:1044-1549
1535-4989
DOI:10.1165/rcmb.2021-0423ED