A Highly Sensitive, Excimer-Controlled Molecular Beacon
Non‐nucleosidic chromophores in the stem of a molecular beacon inhibit excimer fluorescence through the formation of a donor–acceptor complex (see picture). The excellent reduction of the background fluorescence allows the detection of DNA and RNA targets in the presence of a significant excess of t...
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Published in | Angewandte Chemie (International ed.) Vol. 49; no. 7; pp. 1227 - 1230 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
08.02.2010
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | Non‐nucleosidic chromophores in the stem of a molecular beacon inhibit excimer fluorescence through the formation of a donor–acceptor complex (see picture). The excellent reduction of the background fluorescence allows the detection of DNA and RNA targets in the presence of a significant excess of the probe. |
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Bibliography: | istex:241A95120DC5BABE3EA8CF0C9FEE0C6D3DEA4A3D ArticleID:ANIE200905829 This work was supported financially by the Swiss National Foundation (grant 200020-117617). ark:/67375/WNG-T3RXG0RS-1 Swiss National Foundation - No. 200020-117617 This work was supported financially by the Swiss National Foundation (grant 200020‐117617). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200905829 |