Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial

• Published in: Phytotherapy research Vol. 32; no. 3; pp. 514 - 521
• Main Authors: Alizadeh, Fatemeh, Javadi, Maryam, Karami, Ali Akbar, Gholaminejad, Fereshteh, Kavianpour, Maria, Haghighian, Hossein Khadem
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2018
• Subjects: Anthropometry; antioxidant activity; Antioxidants; Biomarkers; C-reactive protein; Clinical trials; Curcumin; Hormones; infertile men; Infertility; Inflammation; inflammatory factors; Intervention; males; Malondialdehyde; men; Motility; normal values; Oxidative stress; Parameters; patients; Physical activity; placebos; Plasma levels; randomized clinical trials; Semen; Sperm; sperm concentration; spermatogram; spermatozoa; Statistical analysis; Statistical significance; Supplements; therapeutics; Tumor necrosis factor-α; tumor necrosis factors; Urology; spermatogram; infertile men; inflammatory factors; oxidative stress; curcumin
• ISSN: 0951-418X; 1099-1573; 1099-1573
• DOI: 10.1002/ptr.5998

At least 50% of infertile couple's problems are related to male factor infertility. This Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial conducted in Urology unit of Infertility Clinic on 60 infertile men. Patients were randomly assigned to one of intervention and placebo (n = 30) groups. Finally, 28 subjects in each group completed the study. Participants in the intervention group took daily 80 mg curcumin nanomicelle and those in the placebo group took daily placebo for 10 weeks. Semen analysis, anthropometric, physical activity assessments, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at the baseline and at the end of the study. At the end of study, statistically significant differences were seen in the total sperm count, sperm concentration, and motility in the intervention group to the control group. In treatment group, the total sperm count, sperm concentration, and motility levels were also statistically increased at the end of study compared to the baseline values. Curcumin nanomicelle supplementation also resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C‐reactive protein, and tumor necrosis factor a in comparison to the placebo. Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters. However, further investigation is suggested in this regard.