Efficient Synthetic Routes to (±)‐Hippolachnin A, (±)‐Gracilioethers E and F and the Alleged Structure of (±)‐Gracilioether I
Two monocyclic members in the gracilioether family were synthesized in only three steps. The monocyclic products were further elaborated into advanced precursors to hippolachnin A and gracilioether E, respectively. Gracilioether F and the alleged structure for gracilioether I were also synthesized u...
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Published in | Chemistry : a European journal Vol. 23; no. 9; pp. 2026 - 2030 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
10.02.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Two monocyclic members in the gracilioether family were synthesized in only three steps. The monocyclic products were further elaborated into advanced precursors to hippolachnin A and gracilioether E, respectively. Gracilioether F and the alleged structure for gracilioether I were also synthesized using a late‐stage C(sp3)–H thermo‐oxidation.
Members of the family: The carbonyl group at the C‐1 made the C‐2 oxidation more difficult than otherwise. However, eventually the Pb(OAc)4/I2/80 °C conditions worked well where other conditions failed. The last step oxidation along with several other novel steps created a quick route to several members in the gracilioether family, including the alleged structure for gracilioether I. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0947-6539 1521-3765 1521-3765 |
DOI: | 10.1002/chem.201605776 |