Efficient Synthetic Routes to (±)‐Hippolachnin A, (±)‐Gracilioethers E and F and the Alleged Structure of (±)‐Gracilioether I

Two monocyclic members in the gracilioether family were synthesized in only three steps. The monocyclic products were further elaborated into advanced precursors to hippolachnin A and gracilioether E, respectively. Gracilioether F and the alleged structure for gracilioether I were also synthesized u...

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Published inChemistry : a European journal Vol. 23; no. 9; pp. 2026 - 2030
Main Authors Xu, Ze‐Jun, Wu, Yikang
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 10.02.2017
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Summary:Two monocyclic members in the gracilioether family were synthesized in only three steps. The monocyclic products were further elaborated into advanced precursors to hippolachnin A and gracilioether E, respectively. Gracilioether F and the alleged structure for gracilioether I were also synthesized using a late‐stage C(sp3)–H thermo‐oxidation. Members of the family: The carbonyl group at the C‐1 made the C‐2 oxidation more difficult than otherwise. However, eventually the Pb(OAc)4/I2/80 °C conditions worked well where other conditions failed. The last step oxidation along with several other novel steps created a quick route to several members in the gracilioether family, including the alleged structure for gracilioether I.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.201605776