LiBr as an Efficient Catalyst for One-pot Synthesis of Hantzsch 1,4-Dihydropyridines under Mild Conditions

• Published in: Chinese journal of chemistry Vol. 29; no. 1; pp. 118 - 122
• Main Author: Yadav, D. K. Patel, R. Srivastava, V. P. Watal, G. Yadav, L. D. S
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 2011; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: 1,4‐dihydropyridines; 4-dihydropyridines; Chemistry; Chemistry, Multidisciplinary; cyclization; Hantzsch reaction; lithium bromide; multicomponent reactions; one-pot procedure; Physical Sciences; Science & Technology; 一锅合成; 三组分; 二氢吡啶; 杂环醛; 温和条件; 溴化锂; 缩合反应; 高效催化剂; multicomponent reactions; one-pot procedure; ACID; SOLID-PHASE SYNTHESIS; cyclization; POLYHYDROQUINOLINE DERIVATIVES; lithium bromide; CONDENSATION; 1,4-dihydropyridines; BIGINELLI; Hantzsch reaction; IONIC LIQUIDS; FACILE; ORGANOCATALYTIC TRANSFER HYDROGENATION
• ISSN: 1001-604X; 1614-7065
• DOI: 10.1002/cjoc.201190036

A simple, inexpensive and efficient one-pot synthesis of 1,4-dihydropyridines has been accomplished via lithium bromide-catalyzed Hantzsch three-component condensation reaction of an aldehyde, α,β-ketoester and ammonium acetate in acetonitrile at room temperature in good to excellent yields. The present protocol is applicable to wide range of substrates including aliphatic, aromatic and heterocyclic aldehydes affording 1,4-dihydropyridines.