Lymph Node Metastases in the Gastrocolic Ligament in Patients With Colon Cancer

• Published in: Diseases of the colon & rectum Vol. 57; no. 7; pp. 839 - 845
• Main Authors: Bertelsen, Claus A, Bols, Birgitte, Ingeholm, Peter, Jansen, Jens E, Jepsen, Lars V, Kristensen, Bent, Neuenschwander, Anders U, Gögenur, Ismail
• Format: Journal Article
• Language: English
• Published: Hagerstown, MDc The American Society of Colon and Rectal Surgeons 01.07.2014; Lippincott Williams & Wilkins
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Colectomy - methods; Colon, Transverse - pathology; Colon, Transverse - surgery; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Ligaments - pathology; Ligaments - surgery; Lymphatic Metastasis; Male; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Retrospective Studies; Stomach; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Human; Ligament; Colonic flexures; Malignant lymphadenopathy; Malignant hemopathy; Malignant tumor; Colonic disease; Lymph node metastasis; Colon cancer; Lymph node metastases; Complete mesocolic excision; Gastroenterology; Digestive diseases; Intestinal disease; Transverse colon; Gastrocolic; Gastrocolic ligament; Cancer
• ISSN: 0012-3706; 1530-0358
• DOI: 10.1097/DCR.0000000000000144

BACKGROUND:Long-term survival after colorectal cancer may be improved by more extensive resection of the primary tumor and lymph nodes. Resection of the gastroepiploic and infrapyloric lymph nodes in the gastrocolic ligament has been proposed as a standard procedure when resecting tumors located in the proximity of the flexures or in the transverse colon. OBJECTIVE:The purpose of this work was to present our findings of metastases in the gastrocolic ligament in a consecutive series of patients. DESIGN:This was a single-center retrospective study. SETTINGS:The study was conducted in a colorectal cancer center. PATIENTS:All of the colon adenocarcinoma resections with relevant tumor location from June 1, 2008, to December 31, 2012 were included in this study. MAIN OUTCOME MEASURES:The presence of lymph node metastases in the gastrocolic ligament in colon adenocarcinomas located in the proximity of the flexures or in the transverse colon was measured. RESULTS:Gastrocolic resection was performed in 130 patients. Thirty-two patients were excluded because of a lack of information about gastrocolic lymph node status in the pathology reports. Median age of the remaining 98 patients was 70 years (range, 30–90 years), and 57% were men. Gastrocolic lymph nodes were found in 86 specimens (88%) with a median number of 4 lymph nodes (range, 0–16 lymph nodes). Thirty-four patients (35%) had mesocolic lymph node metastases. Gastrocolic lymph node metastases were found in 4 (12%) of these 34 patients and in 4% of all 98 included patients. Gastrocolic lymph node metastases were related to perineural invasion (p > 0.001). LIMITATIONS:Limitations of this study include the retrospective design, size of material, and lack of gastrocolic ligament lymph node status in the pathology report in some patients. CONCLUSIONS:Metastases in the gastroepiploic or infrapyloric lymph nodes can be found in patients with tumors located in the proximity of the flexures or in the transverse colon. Further studies are needed to reveal the clinical relevance of this finding, with special focus on recurrence risk and long-term survival.