EFFECTS OF THE CALCIUM CHANNEL BLOCKER BENIDIPINE ON MEMBRANE FLUIDITY OF ERYTHROCYTES IN SUBJECTS WITH ESSENTIAL HYPERTENSION: AN ELECTRON PARAMAGNETIC RESONANCE STUDY

SUMMARY 1 In the present study, the effects of benidipine, a long‐acting Ca channel blocker, on the membrane fluidity of erythrocytes in subjects with essential hypertension were examined using an electron paramagnetic resonance (EPR) and spin‐labelling method. 2 Erythrocyte membrane fluidity was si...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 34; no. s1; pp. S67 - S69
Main Author Tsuda, Kazushi
Format Journal Article
LanguageEnglish
Published Melbourne, Australia Blackwell Publishing Asia 01.11.2007
Subjects
benidipine
erythrocytes
hypertension
membrane fluidity
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Summary:SUMMARY 1 In the present study, the effects of benidipine, a long‐acting Ca channel blocker, on the membrane fluidity of erythrocytes in subjects with essential hypertension were examined using an electron paramagnetic resonance (EPR) and spin‐labelling method. 2 Erythrocyte membrane fluidity was significantly lower in hypertensive than normotensive subjects. 3 Benidipine increased the membrane fluidity of erythrocytes from both hypertensive and normotensive subjects in a dose‐dependent manner. The effect of benidipine was more pronounced in hypertensive subjects than in normotensive subjects. 4 The results of the present study suggest that benidipine may have a beneficial effect on the rheological behaviour and the improvement of the microcirculation in hypertension.
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ArticleID:CEP4783
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.2007.04783.x