A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency

Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) rep...

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Published inKorean journal of pediatrics Vol. 53; no. 10; pp. 913 - 916
Main Authors Lee, Won Seok, Park, Young Sil
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Pediatric Society 01.10.2010
Korean Pediatric Society
Subjects
Case Report
Congenital factor VII deficiency
Intracranial hemorrhage
Neonate
Intracranial hemorrhage
Congenital factor VII deficiency
Neonate
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Summary:Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII (NovoSeven®) is currently considered the first-line treatment for replacement therapy of FVII deficiency. Here we present a case of severe intracerebral and intraventricular hemorrhage in a neonate with congenital FVII deficiency.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1738-1061
2092-7258
DOI:10.3345/kjp.2010.53.10.913