Biochemistry to the Rescue: A ClC-2 Auxiliary Subunit Provides a Tangible Link to Leukodystrophy

ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 73; no. 5; pp. 855 - 857
Main Authors Maduke, Merritt C., Reimer, Richard J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.03.2012
Elsevier Limited
Subjects
Biochemistry
Chloride channels
Genes
Genotype & phenotype
Homeostasis
Membranes
Mutation
Neurons
Pathology
Proteins
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Summary:ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.
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ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2012.02.012