Water-soluble Organometallic Analogues of Oxaliplatin with Cytotoxic and Anticlonogenic Activity
Pt prodrugs: We synthesized new cationic complexes [PtCl(η2‐C2H4)(R,R‐chxn)]Cl (1) and [PtCl(η2‐C2H4)(S,S‐chxn)]Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metab...
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Published in | ChemMedChem Vol. 5; no. 1; pp. 46 - 51 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
04.01.2010
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | Pt prodrugs: We synthesized new cationic complexes [PtCl(η2‐C2H4)(R,R‐chxn)]Cl (1) and [PtCl(η2‐C2H4)(S,S‐chxn)]Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metabolites as those of oxaliplatin. |
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Bibliography: | ark:/67375/WNG-73321W66-R istex:ACAE787B5C489938D18F15060FB57687D542BEA3 ArticleID:CMDC200900412 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1860-7179 1860-7187 |
DOI: | 10.1002/cmdc.200900412 |