Water-soluble Organometallic Analogues of Oxaliplatin with Cytotoxic and Anticlonogenic Activity

Pt prodrugs: We synthesized new cationic complexes [PtCl(η2‐C2H4)(R,R‐chxn)]Cl (1) and [PtCl(η2‐C2H4)(S,S‐chxn)]Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metab...

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Published inChemMedChem Vol. 5; no. 1; pp. 46 - 51
Main Authors Benedetti, Michele, Antonucci, Daniela, Migoni, Danilo, Vecchio, Vita M., Ducani, Cosimo, Fanizzi, Francesco P.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 04.01.2010
WILEY‐VCH Verlag
Subjects
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - toxicity
antitumor agents
Cell Line, Tumor
cisplatin
HeLa Cells
Humans
olefin complexes
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - toxicity
Organoplatinum Compounds - chemical synthesis
Organoplatinum Compounds - chemistry
oxaliplatin
platinum
Platinum - chemistry
Stereoisomerism
Water - chemistry
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Summary:Pt prodrugs: We synthesized new cationic complexes [PtCl(η2‐C2H4)(R,R‐chxn)]Cl (1) and [PtCl(η2‐C2H4)(S,S‐chxn)]Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metabolites as those of oxaliplatin.
Bibliography:ark:/67375/WNG-73321W66-R
istex:ACAE787B5C489938D18F15060FB57687D542BEA3
ArticleID:CMDC200900412
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200900412