Evaluation of assays for nucleic acid testing for the prevention of chikungunya and dengue virus transmission by blood transfusion

• Published in: Transfusion (Philadelphia, Pa.) Vol. 64; no. 8; pp. 1503 - 1508
• Main Authors: Gallian, Pierre, Dupont, Isabelle, Lacoste, Marjorie, Brisbarre, Nadège, Isnard, Christine, Delouane, Idriss, Richard, Pascale, Morel, Pascal, Laperche, Syria, Lamballerie, Xavier
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2024; Wiley Subscription Services, Inc; Wiley
• Subjects: Assaying; Blood & organ donations; Blood donors; blood safety; Blood Safety - methods; Blood Transfusion; chikungunya; Chikungunya Fever - blood; Chikungunya Fever - diagnosis; Chikungunya Fever - prevention & control; Chikungunya Fever - transmission; Chikungunya virus; dengue; Dengue - blood; Dengue - diagnosis; Dengue - prevention & control; Dengue - transmission; Dengue fever; Dengue Virus; Disease transmission; Humans; International standards; level of detection; Life Sciences; Limit of Detection; NAT; Nucleic Acid Amplification Techniques - methods; Nucleic acids; Outbreaks; Performance evaluation; Ribonucleic acid; Risk analysis; RNA; RNA, Viral - analysis; RNA, Viral - blood; Sensitivity analysis; Sensitivity and Specificity; Vector-borne diseases; NAT; blood safety; level of detection; dengue; chikungunya

Background The large dengue (DENV) and chikungunya (CHIKV) outbreaks observed during the last decade across the world, as well as local transmissions in non‐endemic areas are a growing concern for blood safety. The aim of this study was to evaluate and compare the sensitivity of nucleic acid tests (...