2,5-Diketopiperazines from the Marine-Derived Fungus Aspergillus fumigatus YK-7
Five new diketopiperazines, prenylcyclotryprostatin B (1), 20‐hydroxycyclotryprostatin B (2), 9‐hydroxyfumitremorgin C (3), 6‐hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine‐derived fungus Aspergillus fumigatus YK‐7, along with nine known compounds, 6–14. Their struc...
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Published in | Chemistry & biodiversity Vol. 9; no. 2; pp. 385 - 393 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Zürich
WILEY-VCH Verlag
01.02.2012
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | Five new diketopiperazines, prenylcyclotryprostatin B (1), 20‐hydroxycyclotryprostatin B (2), 9‐hydroxyfumitremorgin C (3), 6‐hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine‐derived fungus Aspergillus fumigatus YK‐7, along with nine known compounds, 6–14. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC‐3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth‐inhibitory activities against U937 cell line, with the IC50 values of 1.8, 0.2, and 0.5 μM, respectively. |
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Bibliography: | ArticleID:CBDV201100061 ark:/67375/WNG-ZKGCPZMZ-1 istex:134CF66116218F331B6F48D4221ED20B8E3CC791 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1612-1872 1612-1880 |
DOI: | 10.1002/cbdv.201100061 |