Effects of the Brazilian phytopharmaceutical product Ierobina ® on lipid metabolism and intestinal tonus

• Published in: Journal of ethnopharmacology Vol. 102; no. 2; pp. 137 - 142
• Main Authors: Botion, L.M., Ferreira, A.V.M., Côrtes, S.F., Lemos, V.S., Braga, F.C.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 14.11.2005; Elsevier
• Subjects: Animals; Anti-dyspeptic agent; Biological and medical sciences; Blood Glucose - analysis; Brazil; Brazilian phytopharmaceutical product; Carbachol - pharmacology; Carbachol pre-contracted ileum; Dose-Response Relationship, Drug; Dyspepsia - drug therapy; General pharmacology; In Vitro Techniques; Intestines - drug effects; Intestines - physiology; Lipid Metabolism - drug effects; Lipoprotein Lipase - metabolism; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - therapeutic use; Rats; Total lipoprotein lipase activity; Triacylglycerol content; Triglycerides - blood; South America; Brazil; America; Anti-dyspeptic agent; Brazilian phytopharmaceutical product; Total lipoprotein lipase activity; Triacylglycerol content; Carbachol pre-contracted ileum; Antiglaucomatous agent; Agonist; Lipids; Myotic; Esterases; Lipoprotein lipase; Small intestine; Medicinal plant; Tnacylglycerol content; Cholinergic receptor; Nicotinic receptor; Digestive system; Enzyme; Pharmacognosy; Metabolism; Ileum; Carboxylic ester hydrolases; Parasympathomimetic; Carbachol; Content; Plant origin; Hydrolases; Muscarinic receptor; Pharmacokinetics
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2005.05.046

Ierobina ® is a Brazilian phytopharmaceutical product indicated for the treatment of dyspepsia. It contains the hydroethanolic extracts of Solanum paniculatum L. (Solanaceae), Remijia ferruginea D.C. (Rubiaceae), Jacaranda caroba D.C. (Bignoniaceae) and Erythraea centaurium (L.) Borkh. (Gentianaceae), species traditionally used to treat gastrointestinal disorders. The effect of Ierobina ® on the digestive system was investigated in rats fed with normal or high-fat (HF) diets, at doses of 2.16, 4.32 and 8.64 mg/kg. The product did not affect the plasmatic levels of glucose, total cholesterol and HDL-cholesterol in the evaluated doses, whereas the triacylglycerol (TAG) concentration showed a dose-dependent increase in HF-fed animals. TAG-rich lipoprotein uptake, estimated by measuring total lipoprotein lipase activity in epididymal adipose tissue, was accompanied by TAG increase in HF-fed rats, after Ierobina ® administration. The product also induced a concentration-dependent relaxant effect on spontaneous ileum contractions and on the rat ileum pre-contracted with carbachol. Together, these results support the indication of Ierobina ® as an anti-dyspeptic agent.