Experience with photodynamic therapy in Hailey-Hailey disease

Hailey-Hailey disease (HHD) is a rare genodermatosis that is often difficult to treat. This paper reports three patients with HHD treated with one session of photodynamic therapy (PDT) using topical methyl aminolevulinic acid applied under occlusion for 3 hours and red light at 37 J cm2 for 7.5 minu...

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Bibliographic Details
Published inThe Journal of dermatological treatment Vol. 19; no. 5; pp. 288 - 290
Main Authors Guarino, Montse Fernández, Ryan, Ainhoa Marquet, Harto, Antonio, Pérez-García, Bibiana, Arrázola, Jose María, Jaén, Pedro
Format Journal Article
LanguageEnglish
Published Oslo Informa UK Ltd 2008
Taylor & Francis
Subjects
Adult
Biological and medical sciences
Bullous diseases of the skin
Dermatology
Female
Humans
Male
Medical sciences
Pemphigus, Benign Familial - drug therapy
Pemphigus, Benign Familial - pathology
Photochemotherapy
Bullous dermatosis
Case study
Human
Skin disease
Experience
Hailey Hailey disease
Photodynamic therapy
Treatment
Hailey-Hailey disease
Genetic disease
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Summary:Hailey-Hailey disease (HHD) is a rare genodermatosis that is often difficult to treat. This paper reports three patients with HHD treated with one session of photodynamic therapy (PDT) using topical methyl aminolevulinic acid applied under occlusion for 3 hours and red light at 37 J cm2 for 7.5 minutes. Our results are not successful: all of the patients suffered discomfort during the 3-4 weeks following PDT and only one patient experienced clinical improvement. None of the patients would like to repeat the treatment. PDT is at an exploratory stage; further studies are necessary to determine whether PDT is useful in the treatment of HHD.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0954-6634
1471-1753
DOI:10.1080/09546630801958220