Prognostic Value of Neutrophil-Lymphocyte Ratio in Cardiogenic Shock: A Cohort Study

• Published in: Medical science monitor Vol. 26; p. e922167
• Main Authors: Peng, Yangpei, Wang, Jie, Xiang, Huaqiang, Weng, Yingbei, Rong, Fangning, Xue, Yangjing, Ji, Kangting
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 18.05.2020
• Subjects: Aged; Aged, 80 and over; Biomarkers - blood; Cohort Studies; Database Analysis; Databases, Factual; Female; Humans; Inflammation - pathology; Kaplan-Meier Estimate; Leukocyte Count - methods; Lymphocyte Count - methods; Lymphocytes - pathology; Male; Middle Aged; Neutrophils - pathology; Prognosis; Proportional Hazards Models; Retrospective Studies; ROC Curve; Shock, Cardiogenic - immunology; Shock, Cardiogenic - mortality; Shock, Cardiogenic - pathology
• ISSN: 1643-3750; 1234-1010; 1643-3750
• DOI: 10.12659/MSM.922167

BACKGROUND Inflammation plays an important part in the pathogenesis of cardiogenic shock (CGS). Whether the neutrophil-lymphocyte ratio (NLR), an integrated biomarker of inflammation, is associated with the outcome of CGS patients remains unknown. This retrospective cohort study was performed to identify the utility of using NLR among patients with CGS. MATERIAL AND METHODS Data were extracted from the MIMIC database. We applied smooth curve fitting to define the NLR cutoff values. The primary outcome was 30-day mortality. Cox proportional hazards models, subgroup analysis, and receiver operator characteristic (ROC) curve analysis were performed. RESULTS A total of 1470 CGS patients were extracted, among which 801 (54.5%) were men. The mean age of the population was 70.37 years. An inverse U-shaped relationship was observed between NLR and mortality in CGS patients, with the highest risk being at values ranging from 9.4 to 15. For the primary outcome of 30-day mortality, the adjusted HR (95% CI) values of the middle tertile (NLR 9.4-15) and the upper tertile (NLR >15) were 1.47 (1.14, 1.88) and 1.22 (0.94, 1.57) compared with the reference of lower tertile (NLR <9.4). ROC curve analysis showed that NLR had a more sensitive prognostic value in predicting 30-day mortality of CGS than the neutrophil or lymphocyte percentage alone (0.660 vs. 0.540, 0.549). CONCLUSIONS An inverse U-shaped curve was presented between NLR and the mortality of CGS. NLR seemed to be a readily available and independent prognostic biomarker for patients with CGS. The prognostic value of NLR was more sensitive than the neutrophil or lymphocyte percentage alone, but not as good as SOFA or SAPSII score.