Orthobiologics for Bone Healing

Orthobiologics are a group of biological materials and substrates that promote bone, ligament, muscle, and tendon healing. These substances include bone autograft, bone allograft, demineralized bone matrix, bone graft substitutes, bone marrow aspirate concentrate, platelet-rich plasma, bone morphoge...

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Bibliographic Details
Published inClinics in sports medicine Vol. 38; no. 1; p. 79
Main Authors Calcei, Jacob G, Rodeo, Scott A
Format Journal Article
LanguageEnglish
Published United States 01.01.2019
Subjects
Animals
Biological Therapy
Bone Diseases - therapy
Bone Transplantation
Cell- and Tissue-Based Therapy
Humans
Intercellular Signaling Peptides and Proteins - therapeutic use
Intracellular Signaling Peptides and Proteins - therapeutic use
Platelet-Rich Plasma
Sports Medicine - trends
Bone grafting
Fracture healing
Nonunion
Tendon-to-bone
Bone healing
Orthobiologics
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Summary:Orthobiologics are a group of biological materials and substrates that promote bone, ligament, muscle, and tendon healing. These substances include bone autograft, bone allograft, demineralized bone matrix, bone graft substitutes, bone marrow aspirate concentrate, platelet-rich plasma, bone morphogenetic proteins, platelet-derived growth factor, parathyroid hormone, and vitamin D and calcium. Properties of orthobiologics in bone healing include osteoconduction, osteoinduction, and osteogenesis. This article discusses the important properties of orthobiologics in bone healing, many of the orthobiologics currently available for bone healing, the related literature, their current clinical uses in sports medicine, and systemic factors that inhibit bone healing.
ISSN:1556-228X
DOI:10.1016/j.csm.2018.08.005