An overview of current and emerging devices for percutaneous left atrial appendage closure

• Published in: Trends in cardiovascular medicine Vol. 29; no. 4; pp. 228 - 236
• Main Authors: Chow, Danny H.F., Wong, Yam-Hong, Park, Jai-Wun, Lam, Yat-Yin, De Potter, Tom, Rodés-Cabau, Josep, Asmarats, Lluis, Sandri, Marcus, Sideris, Eleftherios, McCaw, Trevor, Lee, Randall J., Sievert, Horst, Søndergaard, Lars, De Backer, Ole
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019; Elsevier Limited
• Subjects: Anticoagulants; Atrial fibrillation; Cardiac arrhythmia; Clinical trials; FDA approval; Feasibility studies; Fibrillation; Ischemia; Left atrial appendage closure; Mortality; Patients; Polyethylene terephthalate; Stroke; Stroke prevention; Transcatheter; United States > US; Stroke prevention; Transcatheter; Atrial fibrillation; Left atrial appendage closure
• ISSN: 1050-1738; 1873-2615
• DOI: 10.1016/j.tcm.2018.08.008

Atrial fibrillation (AF) is common and is a prominent risk factor for ischemic stroke. Oral anticoagulant (OAC) therapy has been the main strategy for stroke prevention in AF patients; however, OAC therapy carries a bleeding risk and is not tolerated by all patients. Left atrial appendage (LAA) closure offers a non-pharmacological alternative for stroke prevention in patients with non-valvular AF. In this update, an overview of current and emerging LAA occluders is given – with special attention to the key design features of every single device and, if available, preclinical or clinical data.