Lymphadenectomy in pancreatic neuroendocrine neoplasms: Why are we still debating?

Pancreatic Neuroendocrine Neoplasms (PNEN) are rare tumours exhibiting very heterogeneous behaviour. For these reasons, studies with high level of evidence are lacking. Whether lymphadenectomy should be performed for PNEN is a matter of debate. In this review, we perform a critical analysis of the a...

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Published inPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 18; no. 8; pp. 855 - 861
Main Authors Ausania, F., Senra del Rio, P.
Format Journal Article
LanguageEnglish
Published Switzerland Elsevier B.V 01.12.2018
Elsevier Limited
Subjects
Classification
Humans
Lymph node
Lymph Node Excision
Lymphatic system
Medical prognosis
Metastases
Metastasis
Morphology
Neuroendocrine
Neuroendocrine tumors
Neuroendocrine Tumors - surgery
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - surgery
Survival Analysis
Tumors
Lymph node
Neuroendocrine
Metastasis
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Summary:Pancreatic Neuroendocrine Neoplasms (PNEN) are rare tumours exhibiting very heterogeneous behaviour. For these reasons, studies with high level of evidence are lacking. Whether lymphadenectomy should be performed for PNEN is a matter of debate. In this review, we perform a critical analysis of the available literature regarding the clinical significance of lymphnode metastases, the importance of lymphadenectomy, and the implications on disease-specific survival.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2018.09.005