Role of the fibroblast growth factor 19 in the skeletal system

• Published in: Life sciences (1973) Vol. 265; p. 118804
• Main Authors: Chen, Hao, Li, Jiazhou, Zhang, Demao, Zhou, Xuedong, Xie, Jing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.01.2021; Elsevier BV
• Subjects: Animals; Biomedical materials; Bone Development - physiology; Bone Diseases - genetics; Bone Diseases - metabolism; Bone Diseases - pathology; Bone turnover; Cytokines; Fibroblast growth factor 1; Fibroblast growth factor receptor; Fibroblast growth factor receptors; Fibroblast growth factor19; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblasts; Gene expression; Growth factor receptors; Growth factors; Homeostasis; Humans; Metabolism; Osteoporosis; Skeletal development; Skeletal diseases; Skeletal system; Skeletal diseases; Fibroblast growth factor19; Skeletal development; Fibroblast growth factor receptor
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2020.118804

Fibroblast growth factor family (FGFs) is a kind of cytokine that plays an important role in growth, development, metabolism and disease. During bone development, multiple FGFs and fibroblast growth factor receptors (FGFRs) play important roles. Previous reports have elucidated the great importance of FGF1, 2, 4, 6, 7, 8, 9, 10, and 18 in bone development, and FGF21 and 23 in bone homeostasis and bone regulation. FGF19 was initially found in the human foetal brain, and its gene location is related to osteoporosis pseudoglioma syndrome. Presently, gene chip detection has repeatedly found that FGF19 shows spatiotemporal specificity of gene expression in bone development and bone-related diseases, as well as differences in the protein level, indicating that FGF19 affects the skeletal system. Considering the current insufficient understanding of FGF19 and its potential function in the skeletal system, this review aims to introduce the background of FGF19 in bone, summarise the research progress of FGF19 in the skeletal system, and discuss the role and therapeutic potential of FGF19 in bone development and bone-related diseases. [Display omitted]