Wnt signaling in development and tissue homeostasis

• Published in: Development (Cambridge) Vol. 145; no. 11; p. dev146589
• Main Authors: Steinhart, Zachary, Angers, Stephane
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.06.2018
• Subjects: Cancer; Cell interactions; Cell proliferation; Cell signaling; Embryogenesis; Homeostasis; Regenerative medicine; Signal transduction; Stem cells; Wnt protein; β-Catenin; Wnt protein; Epigenetics; Wnt signaling

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper...