Wnt signaling in development and tissue homeostasis

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper...

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Published inDevelopment (Cambridge) Vol. 145; no. 11; p. dev146589
Main Authors Steinhart, Zachary, Angers, Stephane
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 01.06.2018
Subjects
Cancer
Cell interactions
Cell proliferation
Cell signaling
Embryogenesis
Homeostasis
Regenerative medicine
Signal transduction
Stem cells
Wnt protein
β-Catenin
Wnt protein
Epigenetics
Wnt signaling
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Summary:The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis.
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ISSN:0950-1991
1477-9129
1477-9129
DOI:10.1242/dev.146589